This article presents the second edition of the Trajectories and Origins survey (TeO2), a reference survey on population diversity in France organized jointly by the French Institute for Demographic Studies (INED) and the National Institute of Statistics and Economic Studies (INSEE). A follow-up to TeO1, TeO2 addresses the continued demand for large-scale data to measure the integration of immigrants and their descendants, and the discrimination to which they are exposed. After a complex sampling procedure, questionnaires were completed by 27,181 individuals aged 18–59 representative of the population living in metropolitan France. Immigrants, people from the French overseas departments and regions, and the second generations of these two groups were over-represented. The multi-thematic questionnaire, administered face-to-face in most cases, covers numerous spheres of the respondents’ social lives. The grandchildren of immigrants can be identified for the first time.